Er... OP is missing the tiny eety beety fact that adjusting uTorrent settings will be RELEVANT to your system and your connection speed. And obviously, you shouldn't change preferences if you have no idea what they do.
What anyone should be doing is to add uTorrent as a firewall exception. You should already have this enabled anyway, because Windows Firewall will prompt you whether you want to let uTorrent's traffic through or not from the get-go.
It's best if you actually leave Randomize Port unticked and specify a port of your choosing, preferably a port above 10000. When you specify a port, you have the opportunity to open that port and thus let traffic go through as you please through your router (if you have one). And of course, setting up port forwarding is specific to each router, which help on setting this up can be found on
PortFoward.com.
UPnP stands for Universal Plug and Play. It makes recognition of devices on your network... well, easier, theoretically. I haven't missed it; therefore I've turned it off personally. I would think that this would improve performance through your router by a very, very slight bit... but adjust this at your own discretion.
NAT-PMP, basically, allows for automatic port forwarding. I would trust manual settings and, therefore, if you are forwarding a port yourself, to turn this off.
Setting an automatic download and upload rate is not recommended because uTorrent is probably not smart enough to know your bandwidth allowance... so I would actually keep this unchecked. What you should do is test your connection at
SpeedTest.net, take the numbers IN KILOBYTES (KB) and not KILOBITS (Kb), multiply those numbers by 80% (.8), then put those numbers into your upload and download limits. This way, uTorrent won't rape your bandwidth.
Global connections would be the number of connections to peers that uTorrent will make. Connected per Torrent would be the number of peers that you will make connections to per torrent. Making any of these numbers astronomical will net you no more performance than setting this to a smaller, more realistic number. Depending on your bandwidth allocation through your ISP, I would set this to a more realistic number. See the chart and source that I have
in this thread, which actually covers the same topic this thread does.
Protocol Encryption is a good thing as it encrypts your data going in and out, which means that ISPs can't analyze your P2P traffic and consequently "choke" your transfer rates. (ISPs don't like peer-to-peer.)
The numbers that Ash-Bash puts out are insane. You should never have 60 torrents active, and 63 active downloads when you already specified 60 active? Whoever made the article that Ash-Bash quoted didn't do their math right.

Refer to the aforementioned chart, or you can safely go with something low, like 5 active torrents and 4 active downloads. This will ensure decent speeds with downloading AND uploading, since you won't be struggling to download and upload from a ton of peers. The reason why I say that is because, with the settings Ash-Bash posted, you would be connected to (60 active torrents x 200 possible peers per torrent - 12000 connections, but limited to the 500 global connections you specified earlier). Check your math... it makes more sense when you do, and it ensures that you're not telling uTorrent to do the impossible.
Everything else, I would leave alone, except for the net.max_halfopen parameter. This allows you to make as many connections as you can, but setting this to a high number does nothing if your TCP/IP settings won't allow it.
LvlLord's Event 4226 TCPIP.sys patch lifts the limitations of XP and Vista as far as connections go (implemented by Microsoft as a propogation measure in the case of infection by malware) but there's only so much you can gain by applying this patch and modifying this parameter.
Again, I want to refer to you to
my previous post in the other uTorrent thread for more information. There's a lot of false information out there... so common sense rules all.
Remember that these settings are dependent to your bandwidth allowance. There are no magic numbers for uTorrent that will make rocket go boom.